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Clinical Trials

All Clinical Trial Listings

Please click the links below to go to each Clinical Trial Listing on this page:

Pilot   -   Phase 1   -   Phase 1 & 2   -   Phase 2   -   Natural History   -   Screening   -   Other

 

All Clinical Trials Information

Protocol Number Title Study Status PI Website Section
Pilot
01C0030 Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas  Open to Accrual Wyndham Wilson Link Hematologic Diseases
07C0086 Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures Open to Accrual Lori Wiener   GVHD, Psychosocial, Transplant
07C0206 A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors Open to Accrual Crystal Mackall Link Sarcoma
08C0051 A Pilot Trial of WT1 Peptide-Loaded Allogeneic Dendritic Cell Vaccine and Donor Lymphocyte Infusion for WT1-Expressing Hematologic Malignancies Open to Accrual Alan Wayne Link Hematologic/Blood Cancers
08C0148 A Pilot Study of Imatinib Mesylate in Children and Adults with Sclerotic Skin Changes of Chronic Graft-Versus-Host Disease  Open to Accrual Edward Cowen Link  
10C0030 A Study of Bevacizumab, a Humanized Monoclonal Antibody Against Vascular Endothelial Growth Factor (VEGF), in Combination with Chemotherapy for Treatment of Osteosarcoma Open to Accrual Su Young Kim   Sarcoma
10C0105 A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children with Gliomas Open to Accrual Kathy Warren   NeuroOncology
11C0113

A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma

Open to Accrual Crystall Mackall   Sarcoma
Phase I
Protocol Number Title Study Status PI Website Section
06C0233 A Phase I Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772 IND# 69896) in Children with Refractory Solid Tumors or Refractory Leukemias Open to Accrual Brigitte Widemann Link Pharmacology & Experimental Therapeutics, Sarcoma, Hematologic Diseases
08C0007 A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer Open to Accrual Crystal Mackall Link Pharmacology & Experimental Therapeutics, Sarcoma
08C0123 A Phase 1, Multi-Center, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults with Refractory CD22+ Acute Lymphoblastic Leukemia (all) or Non-Hodgkin's Lymphoma (NHL) Open to Accrual Alan Wayne Link Pharmacology & Experimental Therapeutics, Hematologic Diseases
08C0180 Phase I Trial of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, Nexavar) in Children and Young Adults with Neurofibromas Type 1 and Inoperable Plexiform Neurofibromas Open to Accrual Brigitte Widemann Link Pharmacology & Experimental Therapeutics, Neurofibromas
09C0243 A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose)Polymerase and Temozolomide in Children with Recurrent/Refractory CNS Tumors Clinical Hold Kathy Warren Link NeuroOncology, Pharmacology & Experimental Therapeutics
10C0119 A Phase 1 Study of Vorinostat and Bortezomib in Children with Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Open to Accrual Brigitte Widemann   Pharmacology & Experimental Therapeutics, Hematologic Diseases, Sarcoma, NeuroOncology
10C0120 A Phase I Study of Pazopanib as a Single Agent for Children with Refractory Solid Tumors Open to Accrual Brigitte Widemann   Pharmacology & Experimental Therapeutics, Sarcoma
11C0047 Phase I Trial and Pharmacokinetic Study of the Oral Platinum Analog Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors Open to Accrual Brigitte Widemann Link Pharmacology & Experimental Therapeutics, Sarcoma, NeuroOncology
10C0219

A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas

Open to Accrual Kathy Warren Link NeuroOncology
Phase 1 & 2
Protocol Number Title Study Status PI Website Section
07C0189 Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma Open to Accrual Brigitte Widemann Link Pharmacology & Experimental Therapeutics, Medullary Thyroid Carcinoma
Phase 2
Protocol Number Title Study Status PI Website Section
04C0173 Phase II Study of UCN-01 in Relapsed or Refractory Systemic Anaplastic Large Cell and Mature T-Cell Lymphomas  Open to Accrual Wyndham Wilson Link Hematologic Diseases
06C0043 Phase II Trial of Chemotherapy in Sporadic and Neurofibromas Type 1 Associated High Grade Malignant Peripheral Nerve Sheath Tumors Open to Accrual Brigitte Widemann Link Neurofibromatosis, Solid Tumors
08C0080 SARC Global Collaboration*: A Phase II Trial of R1507, a Recombinant Human Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor for the treatment of Patients with Recurrent or Refractory Ewing’s Sarcoma, Osteosarcoma, Synovial Sarcoma, Rhabdom Open to Accrual Lee Helman Link Solid Tumors
08C0096 A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromas Type 1 Related Plexiform Neurofibromas Open to Accrual Brigitte Widemann Link Neurofibromatosis
08C0130 A Phase II Trial of Peginterferon alfa-2b (Pegintron) for Neurofibromatosis Type I Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas Open to Accrual Brigitte Widemann Link Neurofibromatosis
09C0104 A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung Open to Accrual Su Young Kim Link Solid Tumors
11C0115

Phase 2 Study of Bevacizumab in Children and Adults with Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma

Open to Accrual Brigitte Widemann  

Neurofibromatosis

 

Natural History
Protocol Number Title Study Status PI Website Section
04C0275 Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity  Open to Accrual Robert Yarchoan Link  
08C0079 Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromas Type 1 Open to Accrual Brigitte Widemann Link Neurofibromas
Screening
Protocol Number Title Study Status PI Website Section
01C0157 Eligibility Screening and Tissue Procurement for the National Cancer Institute (NCI), Pediatric Oncology Branch (POB) Clinical Research Protocols Open to Accrual Crystal Mackall Link All
Other
Protocol Number Title Study Status PI Website Section
06C0233 Psychological Benefits of a Normalized Camping Experience for Children with Cancer Open to Accrual Stephen Chanock   Psychosocial
98C0037 Treatment of Children with Cancer Open to Accrual Crystal Mackall   All
02C0313 CANCER RISK IN XERODERMA PIGMENTOSUM HETEROZYGOTES Open to Accrual Kenneth Kraemer Link  
03C0278 A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI) Open to Accrual Kathy Warren Link NeuroOncology
04C0102 Hematologic Malignancy Biology Study Open to Accrual Alan Wayne   Hematologic Diseases
06C0219 An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors Open to Accrual Kathy Warren Link NeuroOncology
07C0085 An Exploratory Study of the Use of Five Wishes as a Tool for Advanced Care Planning in Young Adults with Metastatic, Recurrent, or Progressive Cancer or HIV Infection Open to Accrual Lori Wiener   Psychosocial
07C0110 Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-approved Protocols Open to Accrual Rohan Hazra    
09C0054 A Group Wide Biology and Banking Study for Phase II Studies of R1507 Open to Accrual Lee Helman   Sarcoma
09CN148 Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma Closed to Accrual Kathy Warren   NeuroOncology
10C0019 Development and validation of a symptom scale for children with chronic graft-versus-host disease Closed to accrual Lori Wiener Link GVHD (and psychosocial)
10C0086 Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies Open to Accrual Javed Khan   Sarcoma, NeuroOncology
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