NIH scientists map genetic changes that drive tumors in a common pediatric soft-tissue cancer
Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.August 22, 2013
Annette Weller’s trees of life
Annette Weller’s daughter Lauren died Dec. 14, 2011, when she was 26. She had Ewing’s sarcoma, a type of bone cancer. Weller painted a tree on a window in the pediatric unit of National Institutes of Health Clinical Center shortly before Lauren passed away. Weller has since returned numerous times to paint more of the clinic’s windows.June 13, 2013
Dr. Brigitte Widemann received the prestigious
Von Recklinghausen Award.
Dr. Brigitte Widemann received the prestigious Von Recklinghausen Award at the 2013 Children’s Tumor Foundation conference in Monterrey CA,
This award recognizes a researchers and/or clinician who have made major contributions to research for neurofibromatosis, at the bench or in the clinic. Previous awardees include Dr. Francis Collins, Dr. Bruce Kort and Dr. John Mulvihill, among others.
The organizers cited Dr. Widemann's international leadership in the conduct of cutting edge clinical trials for Neurofibromatosis and the effectiveness with which she has worked with preclinical consortium to drive new clinical trials in these diseases.
May 25, 2013
Annual POB Research Day
The following individuals were selected for the most outstanding
presentations in their respective categories:
Adrienne Long (Immunology Section)
Stephen Highfill (Immunology Section)
Jeffrey Huo (Johns Hopkins/NCI Pediatric Hematology/Oncology Fellowship)
SU2C-St. Baldrick’s Pediatric Cancer Dream Team: Immunogenomics to Create New Therapies for High-Risk Childhood Cancers
The Pediatric Cancer Dream Team is led by Drs. John M. Maris, director of the Center for Childhood Cancer Research at The Children’s Hospital of Philadelphia, and Crystal L. Mackall, chief of the Pediatric Oncology Branch of the National Cancer Institute (NCI) in Bethesda, Maryland. Members of the team hail from five other institutions across North America. Due to the policies of SU2C and St. Baldrick’s, none of the Dream Team funds will go to the NCI, but its participation will be invaluable.
To read more about Drs. John M. Maris and Crystal L. Mackall and the Pediatric Cancer Dreamplease visit Standup2cancerDreamTeam
August 30, 2012
Camp Fantastic 2012 Survivor Medley
This music video is in honor of all Camp Fantastic and Special Love campers past and present!
Camera on Cancer Research: Unraveling the Molecular Mechanisms of Neuroblastoma
Dr. Carol Thiele, Head of the Cell and Molecular Biology Section in the Pediatric Oncology Branch, takes you into her lab where she researches the molecular mechanisms of neuroblastoma cells.
To view the CCR connections video highlighting Dr. Carol Thiele please visit
Childhood Cancers in Translation
Alan Wayne, M.D., Head of the Hematologic Diseases Section of CCR's Pediatric Oncology Branch, works with a team of investigators to develop novel targeted approaches to treat ALL and other childhood leukemias and lymphomas in hopes that these new therapies will prove more potent and less toxic than those currently available.
To read more about Dr. Wayne and ALL please visit " Childhood Cancers in Translation " at the The CCR Connections website, Volume 4, No 2 2010 edition.
In the Clinic: Alan Wayne, M.D., Head of the Hematologic Diseases Section takes you inside the clinic into the life of Avery LaChapelle, a 11 year old with Acute Lymphoblastic Leukemia. You can read more about Avery's story in the CCR Connections article " He Always Responds "
Inside NCI: A Conversation with Dr. Crystal Mackall about Pediatric Oncology
Dr. Mackall talks about the research in her lab at NCI and areas where pediatric cancer researchers are poised to make major advances.
(Video produced and edited by Daniel Marmorstein and Sarah Curry)
To view the NCI Cancer Bulletin this video is featured on please visit the website at http://www.cancer.gov/ncicancerbulletin/090710/page4.
Pediatric Tumors Made Personal
Javed Khan, M.D., Head of the Oncogenomics Section of CCR’s Pediatric Oncology Branch, has been featured on The CCR Connections website for his approach to study pediatric cancers and his efforts to launch a multicenter project to use comprehensive genomic data to guide the individualized treatment of children with advanced solid tumors.
To read more about Dr. Khan and Pediatric Tumors please visit "Pediatric Tumors Made Personal" at the The CCR Connections website, Volume 4, No 1 2010 edition.