Biography: Brynn Duncan graduated magna cum laude in 2010 from Gettysburg College receiving her Bachelor of Science in Biology with a minor in Chemistry. Her undergraduate research focused on the central role of AMP kinase in mouse oocyte maturation. Brynn began her post-baccalaureate fellowship in the Bone and Marrow Transplant section in July 2010.
Research: Brynn’s research focuses on the use of dipeptidyl peptidase (DPP) inhibitors in the treatment of pediatric solid tumors in mice. These small molecule inhibitors mediate regression of well-established tumors via a T cell-dependent mechanism and are potent adjuvants for vaccines. Brynn is currently working to elucidate the mechanism by which DPP inhibition results in immune-mediated tumor regression as well as optimizing the use of these molecules in conjunction with dendritic cell vaccines in preparation for future clinical trials.