Biography: Nicole Nasholm received her B.S. in Biology from Oregon State University in 2010. While at Oregon State she completed a research project studying ligands of the aryl hydrocarbon receptor as a means of inducing regulatory T cells through IDO-expressing dendritic cells. In July 2010, she joined the Fry Lab as a post-baccalaureate fellow working with Dr. Capitini.
Research: Nicole is expanding her scientific interest in immune tolerance by studying novel strategies to prevent graft-versus-host disease (GVHD) after allogeneic bone marrow transplant. She is examining the biology of blocking the gamma interferon receptor/STAT1 pathway in donor antigen presenting cells as a means of increasing resistance to GVHD mediated by donor lymphocyte infusion.
1. Capitini CM*, Davis JP*, Larabee SM, Herby S, Nasholm NM, Fry TJ: Extracorporeal photopheresis attenuates murine GVHD via bone marrow-derived IL-10 and preserves responses to dendritic cell vaccination, Biology of Blood and Marrow Transplantation 2011 Jan 6 [Epub ahead of print]. * = Co-first authors.