Doo-Yi Oh, Ph.DD
I graduated from Hanyang University, South Korea in 2000. I received Ph.D. in 2005 at the Hanyang University in South Korea. In 2009, I joined NIH as a postdoctoral fellow in the Cell and Molecular Biology Section of the Pediatric Oncology Branch at NCI. My research project focuses on the epigenetic role of polycomb-repressive complex (PRC) that have regulatory function in controlling cell proliferation in BDNF/TrkB pathway of the neuroblastoma (NB) cells. I identified that expression of PRC2 increased during Brain-derived-neurotrophic factor (BDNF) treated neuroblastoma cells. EZH2 is upregulated in aggressive tumors. These models that involved in the regulation of EZH2 will be provided a viable target for therapeutic inhibition in the neuroblastoma tumors.
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