Patrick Grohar, MD PhD, Instructor
Dr. Grohar completed his Ph.D. in the Department of Chemistry at Wayne State University under the supervision of Dr. Christine Chow. His thesis focused on the biochemistry of naturally occurring modified nucleic acids and the synthetic development of modified oligonucleotides to regulate oncogene expression. He subsequently completed his M.D. at Wayne State with distinction in biomedical research. Dr. Grohar did his residency training in the Department of Pediatrics at Johns Hopkins University in the research track spending one year in the lab of Dr. Lee Helman at the National Cancer Institute investigating mTOR signaling in pediatric sarcomas. Subsequent to residency training, he completed fellowship in the joint program at the National Cancer Institute and Johns Hopkins and was chief fellow in his final year. Dr. Grohar currently works in the laboratory of Dr. Lee Helman.
The focus of Dr. Grohar’s research is on drug development for pediatric sarcomas and in particular the Ewing’s sarcoma family of tumors (ESFT). The major emphasis is on the identification and characterization of small molecule inhibitors of the EWS-FLI1 transcription factor for the treatment of Ewing’s sarcoma. The goal is to identify compounds that reverse the activity of this potent oncogene. In addition, Dr. Grohar studies the molecular biology of EWS-FLI1 mediated transcription as well as the identification and characterization of novel molecular targets for ESFT.