Xiaolin Wan, MD PhD, Biologist
Dr. Wan received his M.D. from the Jiang Xi Medical College in 1982. He completed his internship and residency in General Surgery at the second affiliated hospital of Jiang Xi Medical College, serving as the Chief Resident in 1995. He became assistant professor in Department of General Surgery at the second affiliated hospital of Jiang Xi Medical College. He earned his Ph.D. in the Department of Genetics of Medical Institute of Bioregulation Kyushu University, Japan and finished his two-year postdoctoral training in the Department of Ophthalmology at Yale University School of Medicine and two-year postdoctoral training in the Bayview Section of Surgery Science at John Hopkins Medical School. He joined Dr. Lee Helman’s laboratory as a research fellow in 2000 and became a biologist in 2007.
Dr. Wan is focused on understanding signaling pathways involved in the biology of pediatric sarcomas. The long-term goal is to participate in the discovery and development of alternative curative therapies for pediatric sarcomas. Recently, we identified that Bub1b, an essential mitotic checkpoint protein, is necessary for growth and survival of rhabdomyosarcomas by using a loss of function high throughput shRNA screen. The finding may provide a new target for pediatric sarcoma therapy.